Polygenic Risk for Externalizing Disorders
نویسندگان
چکیده
منابع مشابه
Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
In this project, we aimed to bring large-scale gene identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders-based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)-predicted externalizing disorders, subclinical externalizing...
متن کاملAdolescents and Young Adults Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in
In this project, we aimed to bring large-scale gene-identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders—based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)— predicted externalizing disorders, subclinical externalizin...
متن کاملEnvironmental adversity and increasing genetic risk for externalizing disorders.
CONTEXT Studies of gene-environment interplay in the development of psychiatric and substance use disorders are rapidly accumulating. However, few attempts have been made to integrate findings and to articulate general mechanisms of gene-environment influence in the emergence of psychopathology. OBJECTIVE To identify patterns of gene-environment interplay between externalizing disorders (anti...
متن کاملAssociations between Polygenic Risk for Psychiatric Disorders and Substance Involvement
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispani...
متن کاملPolygenic Risk for Externalizing Psychopathology and Executive Dysfunction in Trauma-Exposed Veterans.
The frequent co-occurrence of antisocial behavior and other disinhibited phenotypes reflects a highly heritable externalizing spectrum. We examined the molecular genetic basis of this spectrum by testing polygenic associations with psychopathology symptoms, impulsive traits, and cognitive functions in two samples of primarily military veterans (n =537, n =194). We also investigated whether poly...
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ژورنال
عنوان ژورنال: Clinical Psychological Science
سال: 2014
ISSN: 2167-7026,2167-7034
DOI: 10.1177/2167702614534211